The management of the condition primarily focuses on symptomatic and supportive treatment, including dietary restriction (restricting amino acids and odd-chain unsaturated fats as precursor substances for propionic acid), carnitine supplementation, and the use of metronidazole and other antibiotics to inhibit intestinal bacteria [20]
A decrease in 5,10-methylene THF can compromise the conversion of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP) by the enzyme thymidylate synthase (TYMS), causing uracil accumulation and thymine depletion
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Explore Epitalon Telomere, circadian rhythm, and longevity support
doi: 10.1007/s11756-022-01280-8 19 Daz-ZoritaM.Fernandez-CanigiaM.GrossoG