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The most common side effects are gastrointestinal (constipation, nausea, diarrhea, vomiting) and typically decrease over time

10.1016/J.TOXLET.2006.07.340 [DOI] [PubMed] [Google Scholar] Zhao H, Wu H, He J et al (2016) Frontal cortical mitochondrial dysfunction and mitochondria-related -amyloid accumulation by chronic sleep restriction in mice

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B12 injections are medically indicated for individuals with a diagnosed B12 deficiency or conditions that impair B12 absorption, such as pernicious anemia, Crohns disease, celiac disease, or a history of gastric bypass surgery

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