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FIGURE 3 5.1.1 Sun protections The key strategy for melasma management is consistent photoprotection through the application of broad-spectrum sunscreens with a notably high level of sun protection factor (SPF) of 50+ and persistent pigment darkening (PPD) of +++ or ++++) (Jansen et al., 2013)

Building upon these insights, novel therapeutic strategies are being developed that leverage pharmacogenomic information (e.g., PNPLA3 I148M-guided therapy) and microbiome-based interventions

It also reinforces a broader lesson from precision medicine: the future may lie not in finding one solution for many diseases, but in understanding what makes each disease unique

Why the caution

Antioxidants are compounds that neutralize free radicalsunstable molecules that can damage cells and accelerate aging and disease