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Summary Keywords hyperthyroidism-induced liver damage, drug-induced liver injury, subacute liver failure, double plasma molecular adsorption system, case report Citation Hou Y, Tong M, Yang Y, Zhou Z, Fu Y, Gou Z, Xi J, Liao X, Li S and Zhu W (2025) Subacute liver failure caused by hyperthyroidism and complicated by drugs: a case report and review of the literature

Basic research supports this mechanism, demonstrating that fructose or HFD exposure induces mitochondrial structural abnormalities, mtDNA depletion, and ATP deficiency, ultimately impairing -oxidation and hepatocyte function

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