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This sympathetic overactivation triggers massive, inappropriate releases of stress hormones, including adrenaline and norepinephrine

Biochem J 337:311317 Pavletich NP, Chambers KA, Pabo CO (1993) The DNA-binding domain of 53 contains the four conserved regions the major mutation hot spots

The emergence of abnormal insulin signaling in AD is likely to be multifaceted and involve complex processes [146]

Partial protection likely reflects differences in tissue types, or the assay protocols used in the other studies, but our results confirm that all the drugs tested exhibit radioprotection at some concentration, in one or both assays (Supplementary Table 4)

Shifting focus from the beta-cell as a passive target to an active participant in disease progression will help identify novel therapeutic approaches, potentially leveraging these unique beta-cell responses and susceptibilities for both treatment and prevention of T1D