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44 KeniryA.OxleyD.MonnierP.KybaM.DandoloL.SmitsG.et al (2012)

Obesity and insulin resistance sustain elevated circulating concentrations of pro-inflammatory cytokines including Tumour Necrosis Factor-alpha (TNF-), Interleukin-1 (IL-1), and Interleukin-6 (IL-6) molecules that promote DNA damage, tumour angiogenesis, and immune evasion

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Patients with primary biliary cholangitis (PBC) or primary sclerosing cholangitis (PSC) accumulate hepatic copper even without exogenous copper supplementation [7]