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Patients who remain on semaglutide or tirzepatide for years tend to maintain their weight loss, with some continuing to lose additional weight even after the first year

Not formally approved for weight loss, though weight reduction occurs as a secondary effect

Two forms of human COMT have been identified, a cytoplasmic soluble form (SCOMT) and a membranebound form (MBCOMT) located in the cytosolic side of the rough endoplasmic reticulum The SCOMT is predominantly expressed in the human liver, intestine and kidney (Taskinen et al., 2003), whereas the membranebound form is more highly expressed in all regions of the human central nervous system (Tunbridge et al., 2006)

I think they have tremendous potential

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