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further observed an upregulation of the tissue inhibitor of metalloproteinase-1 ( TIMP1 ), indicating inhibition of MMPs (120)

For statistical analyses of the data on multiplication rates, biochemical parameters and IC 50 values (given as mean values SEM), the unpaired t-test as well as the Mann-Whitney U Test were employed

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Mechanism of Action Reported in published in-vitro studies as a ligand of amylin receptors in hypothalamic and brainstem cell-line assays