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Importantly, JHU083 treatment reduces immunosuppressive cell populations in murine models, including monocyte and granulocyte-derived suppressive cells, regulatory T cells, and pro-tumor CD4 + Th17 cells [185]

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IGFR can directly activate C (PLC), followed by phospholipid hydrolysis to produce diacylglycerol, or DAG, and inositol-4,4,4-triphosphate, or IP3 [43]