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These enzymes function in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione

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Although CVB downregulates class I HLAs, cells still present HLA bound viral peptides that mostly map to the P2-C protein and are conserved across CVB1 and CVB3 ( Moreover, CVB was shown to persistently infect a human pancreatic ductal cell line ( CVB-associated T1D may also be caused by the viral-associated effects on central tolerance

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No randomized controlled trials exist for musculoskeletal or hormonal applications