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puf-8(/) germline tumors are derived from the failure of meiotic entry in the distal mitotic cells as seen in gld-2(/) gld-1(/) germline tumors, and (2) conversely, gld-2( +/ ) gld-1( +/ )

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Providers should monitor weight trajectory , GI tolerability (nausea, vomiting, constipation) , signs of pancreatitis (persistent severe abdominal pain vomiting), gallbladder disease (RUQ pain, fever, jaundice), hydration/renal function when clinically indicated (risk of AKI with severe GI effects), blood pressure , and glucose metrics (especially if combined with insulin or sulfonylureas due to hypoglycemia risk)

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Oral forms require strict dosing instructions to make sure that enough gets into the body