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Moreover, patients with prior ION were excluded at cohort creation to minimize confounding

The STEP trials demonstrated that participants lost an average of 10-15% of their body weight over 68 weeks, depending on lifestyle adherence and consistency with medication

Together, these mechanisms produce a meaningful reduction in appetite and caloric intake

However, FM + Melatonin rats demonstrated neuroprotective efficacy, as evidenced by an increased number of intact neurons (black arrow) similar to those in normal control samples, moderate restoration of satellite ganglionic cell densities (yellow arrowhead), and a reduced extent of nerve damage (red arrows) (Fig