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(doi:10.1007/s00125-010-1937-z) report that metformin acutely increases plasma levels of glucagon-like peptide 1 (GLP-1) in mice

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Figure 1 13 Pharmacokinetics, bioavailability, and endocrine modulation EA, a natural bioactive present in ellagitannin-rich foods (98), undergoes digestion beginning in the stomach and absorption in the jejunum and ileum (99)

Together, these results demonstrated that PI3K/Akt signaling was involved in the protective effect of GLP-1R