It's important to consider other potential causes, including concurrent medications (such as metformin), vitamin deficiencies, or oral/dental conditions
If there is no improvement with the 1st round, the recommendation is still to do the 2nd round because many times it may start working then
, Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170,000 participants in 26 randomised trials, Lancet , vol
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