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Notably, ammonia is simultaneously generated as a byproduct of glutamine deamination

The activated EPAC2 can further activate Ras protein 1 and phospholipase C, which activate the IP3 and diacylglycerol (DAG) pathways and promote the release of Ca 2+ ( 2+ concentration, thereby promoting the mitochondrial synthesis of ATP, and the release of insulin particles into the blood through exocytosis

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Novo Nordisk Inc., et al., Docket No: 2:25-cv-07329