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Double-immunofluorescence staining of GLP-1R and -smooth muscle actin (-SMA) in kidney sections confirmed the absence of GLP-1R expression in VSMCs of Glp1r VSM/ mice (Figure 1M)

Bydureon was discontinued in US markets as of March 2021

Animal studies have not demonstrated concerning fetal or infant toxicity, though human lactation studies remain minimal

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These outcomes help to stabilize pre-existing atherosclerotic plaques and prevent new ones from forming