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Apremilast, an oral phosphodiesterase 4 (PDE4) inhibitor, in patients with moderate to severe plaque psoriasis: Results of a phase III, randomized, controlled trial (Efficacy and Safety Trial Evaluating the Effects of Apremilast in Psoriasis [ESTEEM] 1)

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They have reported LC exhibits antioxidant effects in different tissues with less NO production, lipid peroxidation and OS index when supplemented with 500 mg/kg/day LC intraperitoneally for 14 consecutive days in surgically menopausal rats [49]