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The fusion peptide demonstrated sleep-promoting effects, influenced neurotransmitter levels (5-HT, glutamate, dopamine, melatonin), and confirmed that the Tat cell-penetrating sequence was the more effective BBB carrier of two tested candidates establishing DSIP as a validated active scaffold for BBB-crossing fusion peptide sleep research and supporting the development of next-generation DSIP-based neuromodulatory tools

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Anti-aggression effects documented at the same 0.5 mg/kg dose showed a 5-fold reduction in physical attacks within aggressive environments, occurring within 12 minutes of administration

Figure 1 To elucidate these emerging insights, this review focuses specifically on hypothyroidism, rather than thyroid disorders in general, and synthesizes current knowledge on the mechanistic, clinical, and therapeutic implications of gut microbiota in this context

Use in a child or adolescent