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In turn, oxidative stress insults upregulate heme, BACH1s ligand and mediator for nuclear export, allowing for gene induction of NRF2-regulated cytoprotective factors (Reichard et al., 2007) (Figure 1)

Land, M.K

[1] The inflammation seen in KP could be caused by repeated mechanical irritation of the hyperkeratotic plugs, including scratching, but also by a decrease in antimicrobial peptides with accreted bacteria colonization, due to loss of sebaceous gland-derived antimicrobial peptides

Last Published 10.01.2025 Effective Date: 10.01.2025 This policy addresses the use of antiemetics for prevention of chemotherapy-induced nausea and vomiting associated with anticancer agents