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Weight of evidence: Overall evidence is Low-Moderate: multiple animal studies and a growing number of small clinical trials suggest benefits across gutbrain signaling, social and behavioral domains, gastrointestinal symptoms, and neurophysiological patterns, yet most human studies rely on caregiver-reported outcomes, lack biomarker integration, and seldom control for diet, comorbidities, or baseline microbiome composition

The one-carbon metabolic network integrates several interconnected metabolic cycles, including the folate cycle, methionine cycle, and trans-sulfuration pathway, to generate and transfer one-carbon units from serine, glycine, and methionine to biomolecules [2, 3]

2018;172(3):409-22.e21

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