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In a thymus-deficient mouse model, spontaneous transfer of certain naturally occurring bacteria (e.g., Escherichia coli ) to mesenteric lymph nodes (MLN), spleen, and liver has been observed

doi:10.1016/s0891-5849(02)01006-7

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We conclude that while a consensus in pharmacogenetic management of APAP in pediatric populations has not been achieved, a systems biology based strategy for comprehensively understanding the ontogenic regulatory pathway as well as the interaction between age and genetic variations are particularly necessary in order to address this question