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It is most common between weeks 4 and 8 of treatment and typically improves with dose stabilization and dietary adjustments

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Notably the activated p53 protein enhances the transcription of several genes (Figure 1) that inhibit IGF-1/AKT and mTOR pathways and prevent cell growth and division after a stress signal 12 14

It is the most bioavailable form of B12, and also the most active, working mostly in our brains, nervous system, and liver (Lindstrand, 1964)

When you are suffering from too much stress, fatigue, anxiety, and even lack of motivation to exercise and eat proper diet, there is a high tendency for you choose unhealthy food and gain weight