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Loading phase: For patients without neurological involvement, the standard regimen is 1 mg hydroxocobalamin intramuscularly three times weekly for two weeks (total of six injections)

FDA described the clinical evidence as inconclusive and preliminary and identified product-characterisation, aggregation, immunogenicity and safety uncertainties

evaluated a 2-week treatment with different doses of larazotide, ranging from 0.5 to 8 mg t.i.d., with daily gluten challenge in 86 celiac disease patients on a gluten-free diet (97)

Numerous S -nitrosylated proteins such as Bcl-2, p53, HIF-1, PTEN, and Src are involved in cell survival, angiogenesis, tumorigenesis, and response to cancer treatment (6368)

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