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5 Dietary chronobiotics and antioxidants: nutritional interventions for healthy aging This section explores oxidative stress as a key mechanistic link between circadian disruption and aging-related cellular dysfunction

The hypertension of D 2 / mice has been related to increased sympathetic and vascular smooth muscle endothelin B receptor (ETBR) activities [11], as well as increased reactive oxygen species (ROS) [12]

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These expression changes caused hepatic fatty acid -oxidation acceleration and lipid synthesis suppression in l-carnitine-fed rats, being consistent with hepatic histopathological changes revealed by oil red O staining analysis