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High incidence of ADH2*1/ALDH2*1 genes among Japanese alcohol dependents and patients with alcoholic liver disease

Further, animal studies have shown that there is an increase in Nrf2 expression, increasing the expression of antioxidant enzymes after acute (Muthusamy et al., 2012) and chronic PE (Gounder et al., 2012)

(2015) Human -glutamyl transpeptidase 1: structures of the free enzyme, inhibitor-bound tetrahedral transition states, and glutamate-bound enzyme reveal novel movement within the active site during catalysis, J

In addition, heme iron, contained in red meat, may facilitate the formation of N-nitro- compounds in the intestinal lumen, leading to DNA adducts that can cause mutations and initiate carcinogenesis [39,41]

J Neurology Neurosurg Psychiatry