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Berger, M

Metformin has been demonstrated to prevent renal tubulointerstitial fibrosis (181) by addressing the reduced energy supply resulting from impaired fatty acid oxidation (FAO) in proximal tubular cells

It also fine-tunes nitric oxide production, improving blood flow to damaged areas so nutrients can arrive and waste products can leaveessential for efficient healing

GSK-3 suppression upregulates Gli1 to alleviate osteogenesis inhibition in titanium nanoparticle-induced osteolysis

[DOI] [PMC free article] [PubMed] [Google Scholar] Nolan RA, Muir R, Runner K, Haddad EK, Gaskill PJ (2019) Role of macrophage dopamine receptors in mediating cytokine production: implications for neuroinflammation in the context of HIV-associated neurocognitive disorders