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ULK1 directly interacts with lactate dehydrogenase (LDH)A, phosphorylates serine-196 and elevates intracellular lactate levels

Materials & methods Samples and immunohistochemistry We searched for information on NET, neuroendocrine carcinoma (NEC), carcinoid, middle ear adenoma/NET, olfactory neuroblastoma, paraganglioma/pheochromocytoma, cauda equina NET (CE-NET), medullary thyroid carcinoma, parathyroid adenoma, Merkel cell carcinoma, and pituitary adenoma/neuroendocrine tumors from pathology files at Tohoku University Hospital (Miyagi, Japan), Osaki Citizen Hospital (Miyagi, Japan), Aichi Prefectural Cancer Center Hospital (Nagoya, Japan), Noe Hospital (Osaka, Japan), Kansai Electric Power Hospital, and Kohnan Hospital (Miyagi, Japan)

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Acetyl-CoA synthetase 2(ACSS2): a review with a focus on metabolism and tumor development