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A nested case control study, where people with MASLD were identified using Medicare claims data and matched to controls without liver disease by birth year, ethnicity, and Medicare enrollment duration, reported that both estrogen-only HRT (OR 1.18, 95% CI 1.00-1.38) and combined estrogen and progesterone HRT (OR 1.25, 95% CI 1.07-1.46) were associated with a higher risk of MASLD compared to postmenopausal women with no history of HRT use (128)

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Ghrelin directly targets the ventral tegmental area to increase food motivation