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Larger, randomized controlled trials (RCTs) with longer follow-up periods are necessary to evaluate the efficacy and safety of topical glutathione more robustly

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Understanding these cell-type-specific ferroptotic signatures provides a foundation for accurate therapeutic strategies in cardiovascular contexts

CLINICAL IMPLICATIONS AND FUTURE DIRECTIONS For clinicians managing patients with MASH and F2-F3 fibrosis, ESSENCE positions semaglutide 2.4 mg weekly as an attractive option for patients with obesity and/or T2DM and high cardiometabolic risk [7]