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To investigate whether NF-B directly activates EAAT3 transcription, we analyzed the DNA sequence of the EAAT3 promoter for potential NF-B binding cis-elements using The Contra V3 software and the JASPAR website (Fig

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While all previous studies of amantadine as an antidyskinetic agent tested its symptomatic effect in PD patients who had established LIDs, the PREMANDYSK trial assessed if early adjunct therapy with amantadine has the potential to reduce dyskinesia risk in levodopa-treated early PD patients without LIDs [135]