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In the SURPASS-1 to 5 trials (N = 6263), nausea (12%24%), diarrhea (12%22%), and vomiting (2%13%) were the most common gastrointestinal ADEs associated with tirzepatide ( The FDA Adverse Event Reporting System (FAERS) database is an invaluable resource for post-marketing surveillance and early detection of drug safety issues

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