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Symptomatic overlap

Oxyntomodulin is a biased agonist relative to GLP-1 1,3 (and exendin-P5 26 ), with a bias towards arrestin recruitment over cAMP production, which would compete for G protein interactions and may contribute to the lack of correlation between the faster G s dissociation and enhanced efficacy when assessing cAMP accumulation in whole cells over an extended timeframe

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It requires neurotrophic support, reduced inflammation, and sufficient neural substrate, meaning enough surviving and newly generated neurons to form the new pathways needed for functional recovery

Both frequentist methods (reporting odds ratio [ROR] (22) and proportional reporting ratio [PRR] (23)) and Bayesian methods (information component [IC] (24) and empirical Bayes geometric mean [EBGM] (25)) of disproportionality analysis were applied to investigate the association between a gastrointestinal AE and GLP-1 RAs