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Vitamin B12 shot side effects Most people tolerate vitamin B12 injections well, but possible side effects include: Mild: soreness or redness at injection site, mild diarrhea, nausea, headache, itching Rare but serious: allergic reactions (rash, swelling, difficulty breathing), low potassium (hypokalemia), dizziness or heart rate changes Get emergency medical help if you have signs of an allergic reaction to Vitamin B12: hives

Thus cell culture experiments may not adequately represent the in vivo situation, and care should be taken when interpreting the results of such studies

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Early studies even suggest it could have a role in addressing complex conditions like Multiple Sclerosis