Structural insights into the triple agonism at GLP-1R, GIPR and GCGR manifested by retatrutide (Structural insights into the triple agonism at GLP-1R, GIPR and GCGR manifested by retatrutide | Cell Discovery)
Eligibility criteria for NHS-funded GLP-1 treatment for weight management include: For semaglutide (Wegovy): BMI 35 kg/m (or 32.5 kg/m for people from South Asian, Chinese, other Asian, Middle Eastern, Black African, or African-Caribbean backgrounds) with at least one weight-related comorbidity For liraglutide (Saxenda): Similar BMI criteria as defined in NICE TA664 Evidence of previous weight management attempts through lifestyle modification Treatment must be initiated within specialist weight management services (Tier 3) Time-limited use as specified in the relevant NICE guidance The referral pathway typically involves: Initial GP consultation: Discuss weight concerns, document BMI and comorbidities, and review previous weight management efforts Tier 2/3 weight management services: Many areas require participation in structured lifestyle programmes before pharmacological intervention Specialist assessment: Referral to specialist weight management services for treatment initiation Ongoing monitoring: Regular review to assess response, tolerability, and continuation criteria Treatment continuation requires achieving the weight loss thresholds specified in the product-specific NICE guidance and SmPCs
Mounjaro is indicated for type 2 diabetes
As more people become aware of these medications and the stigma associated with seeking treatment for obesity ebbs, this demand will continue to rise: Research from the University of Southern California showed a 442% increase in prescriptions for semaglutide between January 2021 and December 2023
PMID 22961902
