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( AD ) Representative fluorescence measurement of RBC (purple) and iRBC (green) within a defined region of interest (ROI)

Chronic neuroinflammation, oxidative stress, and impaired glucose metabolism in the brain are also recognized as contributing factors to disease pathogenesis

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While KYN itself is not neuroactive, it is a branching point for two major metabolic routes: one leading to the synthesis of kynurenic acid (KYNA), which occurs in astrocytes, and another leading to the synthesis of picolinic acid (PA) and quinolinic acid (QA), occurring in microglia, with QA serving as a precursor for nicotinamide adenine dinucleotide (NAD) [25, 26]

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