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Hydration and Movement Consistent hydration helps the kidneys and liver process waste, while regular physical activity has been shown to boost general antioxidant defences over time

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Overaccumulation of ROS is known to cause oxidative stress, which triggers DNA damage and activates early apoptosis 37

In POTS patients, one of the main drivers of the orthostatic tachycardia is the excessive sympathetic activation, which mostly occurs in response to blood pooling in the splanchnic veins upon standing