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A healthy, well-balanced diet should be sufficient for most dogs to produce the amino acids themselves, but there are important instances where supplementation is necessary

When you have that problem, you have the ability for small molecules that are supposed to be inside the gut [to make] their way into your bloodstream, [and] that results in a heightened inflammatory response

Nucleic Acids Res 46 , 59966008 (2018)

However, causation has not been established due to confounding factors, including maternal illness

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