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In a 4-week study of rhIGF-1 in healthy adults, mean 24-hour GH pulsatility decreased by approximately 50% compared with baseline, with partial recovery after cessation [18]

Randomised controlled trial (RCT) The gold standard of clinical evidence

Symptoms include: Persistent fatigue and lack of motivation Decreased libido or erectile dysfunction Loss of muscle mass and strength Weight gain and slower metabolism Mood changes, irritability, and poor focus Reduced bone density A meta-analysis published in Clinical Endocrinology confirmed that TRT significantly increases lean body mass and decreases fat mass in hypogonadal men (Corona et al., 2016)

But excessive levels may not be beneficial especially under certain conditions

2021 Jul 14;16(7):e0254493