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Heatmap representation of the unsupervised hierarchical clustering of ANOVA significant phosphorylation site stoichiometries reflected the cellular conditions well with generally highest stoichiometry in EGF-stimulated samples and lowest in kinase inhibitor treated (Supplementary Fig

The model indicates receptorligand stoichiometry as follows: following a peak in the formation of dimerized receptorligand complex, R 2 L (2:1 complex of R/receptor and L/ligand), an excess concentration of ligand would increase the relative proportion of inactive non-dimerized receptorligand complex, RL (1:1 complex of R and L), while the proportion of active R 2 L complex would decline

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Efcacy and Safety of onceweekly dulaglutide versus insulin glargine in patients with Type 2 Diabetes on metformin and glimepiride (AWARD-2)