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This review highlights the interconnected metabolic and neuronal mechanisms in Parkinsons disease encompassing -synuclein pathology, sirtuin imbalance, and disrupted insulin signaling role in PD and explores incretin and phytomolecules molecule based therapies, often utilized for type 2 diabetes management as complementary multi-target neuroprotective strategies

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Immunol Rev 265:621 Mangan MSJ, Olhava EJ, Roush WR, Seidel HM, Glick GD, Latz E (2018) Targeting the NLRP3 inflammasome in inflammatory diseases

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Hyperammonaemia, anion gap metabolic acidosis, hyperosmolality, hypernatraemia and hypocalcaemia [18, 20, 50] may also develop

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