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In LEADER, 9,340 participants with T2DM and high cardiovascular risk were randomized to liraglutide or placebo (HR = 0.91, 95%CI = 0.801.04) (Marso et al., 2016)

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Instead, care can take place in community hospitals, reducing the cost per patient and allowing more patients to be treated

The STEP (Semaglutide Treatment Effect in People with obesity) trials provide comprehensive evidence for semaglutide's lipid effects, while the SURMOUNT trials establish similar benefits for tirzepatide