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95 Endogenous Nonenzymatic Antioxidants The nonenzymatic antioxidants are characterized by their ability to intercept and terminate free radical chain reactions, and inactivate radicals and oxidants

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The high ROS environment lowers the activation threshold of mast cells, causing them to degranulate inappropriately and release a flood of inflammatory cytokines, including histamine, interleukins, and tumor necrosis factor-alpha (TNF-a)

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Excessive ROS in the lung can trigger lipid peroxidation