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The decline of NAD + with age results from three converging factors: (1) increased activity of CD38, a NADase whose expression increases with age-related chronic inflammation (inflammaging), (2) reduced biosynthesis via the NAMPT (nicotinamide phosphoribosyltransferase) and NMN pathways, and (3) increased demand for NAD+ by PARP-1 to repair increasing oxidative DNA damage

JAMA 331(17):14801491

10.1007/s11033-012-2290-8 55

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Optic atrophy 1 is epistatic to the core MICOS component MIC60 in mitochondrial cristae shape control