Reader KL, Cox NR, Stanton J-AL, Juengel JL
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Studies also found that increased expression of zinc transport protein 7 (ZIP7) in the heart, inhibition of PINK1/Parkin-mediated mitophagy, and exacerbation of cardiac insufficiency and fibrosis in mice were found in an HFD/STZ-induced mouse model, which was reversed by knockdown of ZIP7 [183]
In addition to in situ effects on bone tissue, some natural or engineered EVs also participated in gut microecology in the anti-osteoporotic process, suggesting the involvement of the gutbone axis
Adhering to the Mediterranean diet revealed a reduction in inflammatory markers, including CRP, IL-6, and ICAM-1, emphasizing the potential positive effects on inflammation and endothelial function [51]