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Additionally, glutamate receptors become more sensitive to excitatory stimuli in the presence of neuroinflammation, leading to enhanced excitotoxicity, which damages neurons and accelerates neurodegeneration

The study protocol was pre-registered in ClinicalTrials.gov under the registry number NCT03533556 ( 23/05/2018)

It is used for weight reduction in adults (18 years and above) who are overweight and have a body mass index (BMI) of 28 or more

A peculiar fact on neurodegenerative disorders is that they are normally characterized by an increased ROS production (Loef et al., 2011) and the decline of BBB and BCB (Sengillo et al., 2013) and human studies (Halliday et al., 2016