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N Engl J Med 338:265266 Mannucci E, Ognibene A, Cremasco F et al (2001) Effect of metformin on glucagon-like peptide 1 (GLP-1) and leptin levels in obese non-diabetic subjects

10.1038/ncomms11081 Nat

Effect of GLP-1 agonists on testosterone levels: a systematic review and meta-analysis

Those ingredients include: Tretinoin: has been shown to treat liver spots and minimize photo damage22 Clindamycin: has been shown to fight acne effectively23 Azelaic acid: another acne fighter, according to research24 Zinc pyrithione: a common anti-dandruff ingredient that may also balance your skins microbiome25 Niacinamide: a B vitamin long used in cosmetics to reduce signs of aging26 The anti-aging cream only consists of up to three of those ingredients, namely tretinoin, niacinamide, and azelaic acid

True, they have an earthy flavor that doesnt appeal to everyone