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1,2,6 Because nonantimicrobial sulfonamides lack an arylamine group, they do not produce similar metabolites, which is the reason they do not cross-react in patients who have had nonIgE-mediated reactions to antimicrobial sulfonamides

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Although the prevalence of current smokers was higher in patients randomized to ALC compared with those on placebo, the difference between groups did not achieve statistical significance

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