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How to Distinguish Between Normal Irritation and an Allergic Reaction Normal injection-site itching appears immediately or within a few hours, stays localized to a small circle around the needle entry point, and fades within 24 hours without treatment

It drives multiple-organ functional decline by regulating inflammatory factor secretion, epigenetic remodeling and tissue-specific pathological processes

For example, IL-6 receptor inhibitors, a possible therapeutic option in patients severely ill with COVID-19 who have extensive lung lesions and high IL-6 levels 193 , had beneficial effects on glucose intolerance and insulin resistance in patients with rheumatoid arthritis 194