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b , Top-down view of structural overlay of the active GLP-1R transmembrane domain and the inactive CRF 1 R transmembrane domain (PDB code: 4K5Y) indicates the conformational similarity of ECL2 in the two structures

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The overall response rate was 69.4% (95% CI, 62.4%75.8%) in the selpercatinib group and 38.8% (95% CI, 29.1%49.2%) in the control group

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In this case, dosing is typically calculated based on the subject's body weight, often expressed in micrograms per kilogram (mcg/kg)

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