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4 Neuroinflammation in migraine Neuroinflammation refers to an inflammatory reaction within the CNS, regulated by cytokines, chemokines, reactive oxygen species (ROS), and secondary messengers such as nitric oxide (NO) and prostaglandins (37)

Yet CNS drug development faces a daunting success rate of less than 10%, predominantly due to the brains formidable defense system: the blood-brain barrier (BBB)

The 4-day dietary recalls were evaluated with the Food Processor dietary assessment software program (ESHA Research, Salem, OR) to determine the average daily amount of kilocalories and macronutrient consumption of fat, carbohydrate, and protein in the diet at three different time points during the study

van Wijk, S

Ullah et al